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KMID : 1132720130110040200
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Genomics & Informatics
2013 Volume.11 No. 4 p.200 ~ p.210
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Review of Biological Network Data and Its Applications
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Yu Dong-Hyeon
Kim Min-Soo
Xiao Guanghua
Hwang Tae-Hyun
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Abstract
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Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study.
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KEYWORD
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biological network, disease gene prioritization, gene regulatory networks, genome-wide association study, protein function prediction, protein-protein interaction
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